Prolotherapy, short for Proliferation Therapy is a treatment used to help improve pain, stiffness and function. It involves the injection of a solution, often Hypertonic Dextrose or Glucose, as a treatment for osteoarthritic changes. Research indicates that “Dextrose prolotherapy resulted in clinically meaningful and sustained improvement of knee osteoarthritis-specific symptoms compared with saline injections and at-home exercise.” Demonstrated in a study by Topol et al. in 2015.